Preparation of Polysubstituted Isochromanes by Addition of <i>ortho</i>-Lithiated Aryloxiranes to Enaminones
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The reaction of ortho-lithiated aryloxiranes with various enaminones straightforwardly affords new functionalized isochromanes as mixtures of two epimeric stereoisomers in reasonable to very good yields (50–90%). The two diastereomers, which show a high structural variability, can be easily separated by column chromatography.
创建时间:
2016-02-18



