C–H Bond Functionalization via [1,5]-Hydride Shift/Cyclization Sequence: Approach to Spiroindolenines
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https://figshare.com/articles/dataset/C_H_Bond_Functionalization_via_1_5_Hydride_Shift_Cyclization_Sequence_Approach_to_Spiroindolenines/2215270
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资源简介：
A concise synthesis
of spiroindolenines from 2-substituted (Me,
Et) indoles and 2-(pyrrolidin-1-yl)benzaldehydes has been developed
via a [1,5]-hydride shift/cyclization sequence. This method features
a wide substrate scope and an operationally simple procedure, affording
the spiroindolenines in good to excellent yields and moderate diastereoselectivity
(3.5/1 dr). When the inseparable mixture of spiroindolenine isomers
were washed with isopropyl ether after flash chromatography, the major
isomers could be obtained in up to >20/1 dr.
创建时间：
2016-02-16
