Transhomodimerization of Nectins

Nectins are Ca(2+)-independent cell adhesion molecules which interact homophilically and heterophilically in trans to form cell-cell adhesions (reviewed in (Sakisaka et al., 2007; Takai et al., 2008). Each nectin first forms homo-cis-dimers and then homo- or hetero-trans-dimers through the extracellular region, causing cell–cell adhesion. The Nectin protein family is made up of four members, nectin-1, -2, -3, and -4, all of which have an extracellular region with three Ig-like loops, a single transmembrane region, and a cytoplasmic tail region.

桥粒蛋白是钙离子非依赖性细胞粘附分子，它们在跨膜方向上通过同源和异源相互作用形成细胞间粘附（参见Sakisaka等，2007年；Takai等，2008年的综述）。每个桥粒蛋白首先形成同源顺式二聚体，随后通过细胞外区域形成同源或异源反式二聚体，从而促成细胞间的粘附。桥粒蛋白家族由四个成员组成，包括nectin-1、-2、-3和-4，这些成员均具有一个细胞外区域，该区域包含三个Ig样环、一个单一的跨膜区域和一个细胞质尾区。