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Single cell gene expression profile from wild-type and mutant canine retinas following massively parallel reporter assays using pooled AAV5-promoter-GFP vectors.

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NIAID Data Ecosystem2026-05-02 收录
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Efficacy and specifcity of novel photoreceptor-specific promoters were evaluated in wild-type and mutant (PDE6ß-RCD1 and RPGR-XLPRA2) dogs at advnced stages of retinal degeneration using massively parallel reporter assays. Overall design: Each dog was injected subretinally with a pool of AAV5-promoter-GFP vectors. Five weeks post-injection, neuroretinal punches were collected and dissociated into single cells for scRNASeq analysis.

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2025-07-01
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