Behavioral data file following treatment of laboratory rats with paracetamol

Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders. We had previously postulated that acetaminophen exposure early in life, if combined with antioxidants that prevent accumulation of NAPQI, the toxic metabolite of acetaminophen, might be innocuous. In this study, we administered acetaminophen at or below the currently recommended therapeutic dose to male laboratory rat pups aged 4-10 days. The antioxidants cysteine and mannitol were included to prevent accumulation of NAPQI. In addition, animals were exposed to a cassette of common stress factors: an inflammatory diet, psychological stress, antibiotics, and mock infections using killed bacteria. At age 37-49 days, observation during introduction to a novel conspecific revealed increased rearing behavior, an asocial activity, in animals treated with acetaminophen plus antioxidants, regardless of their exposure to oxidative stress...已有众多研究者基于多项证据提出：发育早期暴露于对乙酰氨基酚（acetaminophen）可诱发神经系统疾病。本课题组此前曾提出假说，若在生命早期暴露于对乙酰氨基酚的同时，联用可阻断其毒性代谢产物NAPQI（N-乙酰对苯醌亚胺）蓄积的抗氧化剂，则该暴露可能无危害。本研究对4~10日龄的雄性实验大鼠幼崽给予剂量不超过现行推荐治疗剂量的对乙酰氨基酚，并同时使用抗氧化剂半胱氨酸（cysteine）与甘露醇（mannitol）以阻断NAPQI的蓄积。此外，实验动物还暴露于一系列常见应激因素：促炎饮食、心理应激、抗生素以及灭活细菌诱导的模拟感染。在实验动物37~49日龄时，将其置于与陌生同类共处的场景中开展观察，结果显示：联用对乙酰氨基酚与抗氧化剂的实验组幼鼠的直立行为（一种非社交性行为）发生率显著升高，且该现象与它们是否暴露于氧化应激无关……