Multi-omics of the esophageal microenvironment in reflux and metaplasia. Response of esophageal cells to bacterial infection

The enrichment of Gram-negative bacteria of oral origin in the esophageal microbiome has been associated with the adenocarcinoma cascade. Here, we examine the esophageal microenvironment in gastro-esophageal reflux disease and metaplasia using multi-omics strategies targeting the microbiome.