Supplementary Material for: TRABECTEDIN AND RADIOTHERAPY IN ENDOMETRIAL STROMAL SARCOMA - A CASE REPORT

Endometrial stromal sarcoma (ESS) is a rare tumor that remains a diagnostic and therapeutic challenge to physicians worldwide. This report depicts the case of a 47-year-old female diagnosed with high-grade ESS (HG-ESS). She underwent several lines of treatment starting with radiotherapy and brachytherapy, followed by multiple lines of treatment including trabectedin over several months. After retreatment with trabectedin and achieving disease stabilization for 10 months, treatment was optimized by trabectedin combined with radiotherapy, leading to stable disease that is still ongoing and lasts for over 17 months. Our case supports the safety of long-term trabectedin and radiotherapy administration in an ESS patient with the maintenance of durable stable disease response in the metastatic setting.