Gonadal gap junctions activate Notch signaling to suppress intestinal innate immunity via p38/PMK-1 and lysosome pathway II

We showed that the innexin genes encoding gap junction subunits positively regulated GLP-1/Notch signaling to suppress the innate immunity of C. elegans via PMK-1/p38 pathway. Overall design: Using vector and inx-14 RNAi in DCL569 ( germline-specific RNAi ) background in the condition of PA14 infection or OP50 fed, then design some different assays to identify the important tips obtained from RNA-seq data analysis.