Hyperuricemia Predisposes to the Onset of Diabetes. Hyperuricemia Predisposes to the Onset of Diabetes

To further examine the mechanisms of urate in islet β-cell death, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish primacy of streptozotocin (STZ) vs. urate. Islets were isolated from Uox-KO and WT mice with and without multiple low-dose STZ. Differentially expressed genes (DEGs) in islets of the hyperuricemic and/or diabetic mice in comparison to their respective controls represented specific Gene Ontology (GO) pathways and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional meanings. Overall design: Diabetic mice models were intraperitoneally injected with multiple low-dose STZ at a dose of 40 mg/kg body weight daily, for 5 consecutive days. Hyperuricemic mice and their counterparts were also included.Four groups (KO, WT, STZ-KO and STZ-WT) were designed with three replications in each.