ALEXA

ALEXA is a microarray design platform for 'alternative expression analysis'. This platform facilitates the design of expression arrays for analysis of mRNA isoforms generated from a single locus by the use of alternative transcription initiation, splicing and polyadenylation sites. We use the term 'ALEXA' to describe a collection of novel genomic methods for 'alternative expression' analysis. 'Alternative expression' refers to the identification and quantification of alternative mRNA transcripts produced by alternative transcript initiation, alternative splicing and alternative polyadenylation. This website provides supplementary materials, source code and other downloads for recent publications describing our studies of alternative expression (AE). Most recently we have developed a method, 'ALEXA-Seq' and associated resources for alternative expression analysis by massively parallel RNA sequencing.

ALEXA是一种专为'替代表达分析'设计的微阵列设计平台。该平台通过利用替代转录起始、剪接和聚腺苷酸化位点，促进了从单一基因座产生的mRNA异构体表达阵列的设计。我们使用术语'ALEXA'来描述一系列针对'替代表达'分析的全新基因组方法。'替代表达'涉及通过替代转录起始、替代剪接和替代聚腺苷酸化产生的替代mRNA转录本的识别和量化。本网站提供了关于我们研究替代表达（AE）的近期出版物所描述的补充材料、源代码以及其他下载资源。最近，我们开发了一种名为'ALEXA-Seq'的方法及其相关的替代表达分析资源，通过大规模并行RNA测序进行。