Genome-wide DNA methylation in post-mortem hippocampus of patients with bipolar disorder and controls

Evidence suggests accelerated aging mechanisms in bipolar disorder (BD), including DNA methylation (DNAm) aging in blood. However, it is unknown whether such mechanisms are also evident in the brain. To investigate this, we interrogated genome-wide DNA methylation in postmortem hippocampus from 32 BD-I patients and 32 age-, sex-, and race-matched non-psychiatric controls from the NIMH Human Brain Collection Core. Infinium MethylationEPIC BeadChip (Illumina) was used to interrogate genome-wide DNA methylation levels in the post-mortem hippocampal tissue of 32 patients with bipolar disorder type I and 32 age-, sex- and race-matched non-psychiatric controls.