Extrachromosomal circular DNAs are ubiquitous in mouse hearts and function as enhancers to promote chromosomal transcription [Circle-seq]

To systematically analyzed the genome-wide characterization of potential eccDNAs in mouse heart tissues, we peformed Circle-seq in embryonic, neonatal and adult mouse heart tissues. EccDNA expression profiling was analyzed to determine what extent eccDNAs occur in different developmental stages of mouse heart tissues (embryonic, neonatal and adult).