Corbat2021 - Apoptotic Reaction Model.models

Apoptotic Reaction Model is an ordinary differential equation model describing every species in the apoptotic cascade and trained to simulate experiments with extrinsic or intrinsic stimuli. It is based on the model introduced by Albeck et al. 2008 and contains a missing feedback between effector caspase 3 and intrinsic caspase 9 to be able to predict results from experiments with either extrinsic and intrinsic stimuli.