Research on the antipruritic active ingredients of Mikania micrantha

The antipruritic effect of petroleum ether, ethyl acetate, ethanol extraction site and volatile oil of Mikania micrantha was determined using a 4-aminopyridine-induced model of itching in mice. GC-MS was used to analyze the components of the antipruritic fractions, combined with mice itch-causing models to study the antipruritic effects of β-Caryophyllene and Humulene. The safety of β-Caryophyllene was preliminarily evaluated through the acute toxicity test of mice skin.