Disulfide stabilized HIV-1 CA hexamer in complex with capsid inhibitor N-(1-(3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-5,6-dihydrocyclopenta[c]pyrazol-1(4H)-yl)acetamide

Disulfide stabilized HIV-1 CA hexamer in complex with capsid inhibitor N-(1-(3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-5,6-dihydrocyclopenta[c]pyrazol-1(4H)-yl)acetamide Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION, ... Authors: Bester, S.M, Kvaratskhelia, M. Deposit date: 2021-10-28 Release date: 2022-10-05 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.37 Å) Cite: Disulfide stabilized HIV-1 CA hexamer in complex with capsid inhibitor N-(1-(3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-5,6-dihydrocyclopenta[c]pyrazol-1(4H)-yl)acetamide To Be Published与衣壳抑制剂N-(1-(3-(4-氯-1-甲基-3-(甲基磺酰胺基)-1H-吲唑-7-基)-4-氧代-3,4-二氢吡啶并[2,3-d]嘧啶-2-基)-2-(3,5-二氟苯基)乙基)-2-(3-(二氟甲基)-5,6-二氢环戊并[c]吡唑-1(4H)-基)乙酰胺结合的二硫键稳定型HIV-1 CA六聚体 描述项：氯离子、衣壳蛋白p24、碘离子…… 作者：Bester S.M.、Kvaratskhelia M. 存入日期：2021-10-28 发布日期：2022-10-05 最后修改日期：2024-11-06 实验方法：X射线衍射（2.37埃） 引用信息：与衣壳抑制剂N-(1-(3-(4-氯-1-甲基-3-(甲基磺酰胺基)-1H-吲唑-7-基)-4-氧代-3,4-二氢吡啶并[2,3-d]嘧啶-2-基)-2-(3,5-二氟苯基)乙基)-2-(3-(二氟甲基)-5,6-二氢环戊并[c]吡唑-1(4H)-基)乙酰胺结合的二硫键稳定型HIV-1 CA六聚体 待发表