Targeting Chop/Ddit3 in β-cells corrects hepatic steatosis and improves glucose tolerance
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
We report that Chop/Ddit3 is a druggable target in pancreatic β-cells for the therapeutic benefits of correcting hepatic steatosis and improving glucose tolerance. Genetic and pharmaceutical manipulation of Chop/Ddit3 levels in β-cells led to whole animal phenotypes and islets physiology change. Transcriptomic changes in these islets were performed to reveal molecular changes.
创建时间：
2019-10-25
