ABCG1
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]
该基因编码的蛋白质属于ATP结合盒（ABC）转运蛋白超家族。ABC蛋白负责将各种分子跨越细胞外和细胞内膜进行运输。ABC基因被划分为七个不同的亚家族（ABC1、MDR/TAP、MRP、ALD、OABP、GCN20、White）。本蛋白属于White亚家族，参与巨噬细胞胆固醇和磷脂的运输，并可能在其他细胞类型中调节细胞脂质稳态。已鉴定出六种不同的剪接变体。[参考资料：RefSeq，2008年7月]
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