Expression data from 4-week-old mouse liver. Expression data from 4-week-old mouse liver

mRNA degradation critically contributes to liver development and function. The CCR4-NOT complex serves as a major deadenylase that initiates mRNA degradation. We used microarrays to identify deregulated genes in the livers lacking CNOT3, a core subunit of the CCR4-NOT complex. Overall design: Liver-specific CNOT3 knockout mice were generated by expressing Cre recombinase under the control of Albumin promoter. Livers from control and CNOT3 knockout mice were used for RNA extraction and hybridization on Affymetrix microarrays.