Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins

ChEBI2014-03-23 更新2026-07-21 收录

干细胞重编程

保守性分析

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-21302 数据链接链接失效反馈

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Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins

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2014-03-23

Reprogramming of mouse somatic cells into pluripotent stem cells using a combination of small molecules

干细胞重编程

化学生物学

Somatic cells can be reprogrammed to generate induced pluripotent stem cells (iPSCs) by overexpression of four transcription factors, Oct4, Klf4, Sox2, and c-Myc. Bmi1 is responsible for conversion o

NIAID Data Ecosystem60

Epigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms [SNP array]

干细胞重编程

神经细胞表观遗传学

Human pluripotent stem cells hold great potential for regenerative medicine, but available cell types have important limitations. While embryonic stem cells derived from fertilized embryos (IVF-ESCs)

NIAID Data Ecosystem40

Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]. Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]

干细胞重编程

染色质可及性调控

Chemical induction of pluripotency (CIP) is an ideal way to reprogram cell fate, but remains poorly understood. Here we report the development of an efficient CIP protocol and the chromatin accessibil

NIAID Data Ecosystem40

Analysis of Differential Proteomes of Induced Pluripotent Stem Cells by Protein-Based Reprogramming of Fibroblasts

干细胞重编程

蛋白质组学比较分析

The recent generation of induced pluripotent stem (iPS) cells represents a novel opportunity to complement embryonic stem (ES) cell-based approaches. iPS cells can be generated by viral transduction o

Figshare2016-02-23 更新50

Establish a rapid and efficient chemical reprogramming platform (RNA-Seq II)

干细胞重编程

表观基因组图谱

Chemically reprogramming somatic cells to iPSCs is time-consuming and low-efficiency. Here, we discribe a rapid chemical reprogramming condition enabling generating iPSCs from MEFs in 12 days. To furt

NIAID Data Ecosystem40

Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins

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