Attenuated kidney oxidative metabolism in young adults with type 1 diabetes. Attenuated kidney oxidative metabolism in young adults with type 1 diabetes

In type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism. Young adults with T1D and healthy controls underwent single-cell RNA sequencing, and spatial metabolomics to assess this relationship. Overall design: Cryostor-preserved kidney biopsies were subjected to single cellular RNA-sequencing. ***Please note that the current study was part of a clinical trial (NCT04074668), and thus raw data are not available due to patient privacy concerns.