EpiRegio

EpiRegio is a resource of Regulatory EleMents (REMs), non-coding DNA regions that are able to regulate the expression of their target genes. Identifying REMs and their associated genes is an ongoing challenge in epigenomics, as there is no method yet to get a clear readout of a REM and as the target genes can be located up to several kilobases away.EpiRegio's data is based on the results of STITCHIT, a peak-calling free algorithm that uses chromatin accessibility signal in combination with gene expression data to identify gene-specific REMs. For each REM, EpiRegio provides you with information on its associated gene, its relevance for its gene's expression and its activity in different cell types and tissues. With EpiRegio you are able to look into regions of interest, analyze the genomic locations that impact the expression of specific genes and access details about the REMs.EpiRegio是一款调控元件（Regulatory Elements，REMs）资源库，这类非编码DNA区域能够调控其靶基因的表达。识别调控元件及其关联基因是表观基因组学领域持续面临的挑战：目前尚无方法可以清晰获取调控元件的完整信息，且靶基因可位于距离调控元件多达数千碱基对的位置。 EpiRegio的数据集基于算法STITCHIT的分析结果，该算法无需进行峰值调用（peak-calling），通过将染色质可及性信号（chromatin accessibility signal）与基因表达数据相结合，来识别基因特异性的调控元件。 针对每个调控元件，EpiRegio可提供其关联基因、该元件对靶基因表达的调控相关性，以及其在不同细胞类型和组织中的活性信息。 借助EpiRegio，用户能够检索目标基因组区域、分析影响特定基因表达的基因组区域，并获取调控元件的详细信息。

搜集汇总

背景与挑战

背景概述

EpiRegio是一个调控元件（REMs）资源库，这些元件是非编码DNA区域，能够调节靶基因的表达。其数据基于STITCHIT算法，通过结合染色质可及性信号和基因表达数据识别基因特异性REMs，并为每个REM提供关联基因、表达相关性以及在不同细胞和组织中的活性信息，支持用户通过基因、区域或API等方式进行查询。