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Transcriptomic analysis of MSTO-211H cell variant resistant to CAR T cell therapy. Transcriptomic analysis of MSTO-211H cell variant resistant to CAR T cell therapy

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NIAID Data Ecosystem2026-03-11 收录
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We developed MPM cells from pleural tumors that had relapsed after treatment with M28z CAR T cells Overall design: We implanted MSTO-211H in the pleura of NSG mice and after 2 weeks we treated mice with CAR T cells. Tumor from mice that relapsed ( 3 mice) were isolated and cells culture in vitro. We generated 3 cell variants from relapsed tumors

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2020-08-21
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