Cell Taxonomy

Cell Taxonomy is a manually curated repository of cell types and associated markers encompassing a wide range of species, tissues and conditions. Cell Taxonomy presents a well-structured taxonomy for curated cell types and incorporates scRNA-seq datasets for millions of single cells to enable further exploration of cell types and markers. Multi-faceted characterization is provided including association analysis of cell types/markers/tissues, cellular component similarity estimation and quality assessment of gene markers and cell clusters. Cell Taxonomy can serve as a fundamental reference cellular resource to help accurate cell type characterization and cell marker selection and support a wide range of single-cell research.细胞分类数据库（Cell Taxonomy）是一个经人工整理注释的细胞类型及其相关标志物资源库，覆盖了广泛的物种、组织与实验条件。该数据库为经人工整理注释的细胞类型构建了结构清晰的分类体系，同时整合了涵盖数百万个单细胞的单细胞RNA测序（single-cell RNA sequencing, scRNA-seq）数据集，以支持对细胞类型与标志物的深入探索。该数据库提供多维度特征分析功能，涵盖细胞类型、标志物与组织的关联分析、细胞组分相似性评估，以及基因标志物与细胞簇的质量评估。该数据库可作为基础的参考细胞资源，助力实现精准的细胞类型注释与标志物筛选，并为各类单细胞研究提供有力支撑。

搜集汇总

背景与挑战

背景概述

Cell Taxonomy是一个综合性细胞分类学数据库，整合了多种资源，包括3,143种细胞类型、26,613个细胞标记、34个物种、387种组织、257种条件和4,299篇相关出版物。该数据库定期更新，例如在2022年整合了大规模人类单细胞图谱，并提供了细胞类型比较和预测等工具，旨在支持细胞多样性和单细胞RNA测序研究。