WGS of RPE-1 cells with PICH deficiency
收藏NIAID Data Ecosystem2026-05-02 收录
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PICH depletion in non-transformed diploid cells RPE-1 induces DNA damage, micronuclei formation, p53 activation, G1-phase arrest, and cell death. Whole-genome sequencing reveals that segregation defects induced by PICH depletion cause chromosomal rearrangements, including translocations and inversions, emphasizing its significance in preserving genomic integrity.
创建时间：
2024-07-03
