Expression Data from Cerulein Treated Pancreas

IFRD1 is required for reserve stem cell proliferation in multiple tissues. Repeated cerulein treatment causes damage and induces proliferation in otherwise terminally differentiated pancreatic acinar cells. We used microarrays to detail gene expression changes in IFRD1 null mice treated with cerulein compared to WT mice treated with cerulein. Adult mouse pancreatic tissue was harvested at 5 days post cerulein injection for RNA extraction and hybridization on Affymetrix microarrays. We aimed to isolate tissue during the proliferative phase of the pancreatic injury response.