RhCl<sub>3</sub>·3H<sub>2</sub>O‑Catalyzed Regioselective C(sp<sup>2</sup>)–H Alkoxycarbonylation: Efficient Synthesis of Indole- and Pyrrole-2-carboxylic Acid Esters
收藏NIAID Data Ecosystem2026-03-11 收录
数据链接：
官方服务：
资源简介：
The C2-selective C–H alkoxycarbonylation of indoles with alcohols and CO catalyzed by RhCl3·3H2O is disclosed that offers convenient access to diverse indole-2-carboxylic esters. The rhodium-based catalysts outperformed all other precious-metal catalysts investigated. In addition, this protocal was found applicable to the synthesis of pyrrole-2-carboxylic esters, and allowed the C–H alkoxycarbonylation in an intramolecular fashion. Preliminary mechanistic studies indicate that C–H cleavage is not likely involved in the rate-determining step, and a five-membered rhodacycle might be an intermediate involved in the reaction.
创建时间：
2019-05-13
相关数据集
暂无相关数据集
