Supplemental materials for the review "Levothyroxine: Conventional and novel drug delivery formulations"

Supplemental materials for the review "Levothyroxine: Conventional and novel drug delivery formulations" Supplementary figure 1. The flow chart of literature selection. Supplementary figure 2. The risk factors of poor compliance. Although the percentages of poor adherence varied in different studies, on average, the percentage of poor adherence based on the Modified Morisky Adherence Scale is estimated to be ~30%, medium adherence ~40% and high adherence ~30%. The Figure was partly generated using illustrative elements from Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license. The figure was not cited in the review. It should been cited in Section 3.4 Paragraph 2. Supplementary table 1. Summary of clinical studies evaluating the bioavailability of liquid LT4 and soft gel capsule in cases with interfering factors. Supplementary table 2. Summary of application of nanomaterials in the drug delivery of levothyroxine.综述《左甲状腺素钠：常规与新型给药制剂》补充材料 补充图1：文献筛选流程图 补充图2：服药依从性差的风险因素。尽管不同研究中服药依从性不佳的占比存在差异，但基于改良Morisky服药依从性量表（Modified Morisky Adherence Scale）的统计结果显示，平均而言，依从性不佳者约占30%，中等依从者约占40%，高依从者约占30%。本图部分使用了Servier提供的Servier医学艺术插图元素，该素材采用知识共享署名3.0未移植许可协议授权。本图未在该综述中引用，应在3.4节第2段中予以引用。 补充表1：存在干扰因素时评估液态左甲状腺素钠与软胶囊生物利用度的临床研究汇总 补充表2：纳米材料在左甲状腺素钠给药系统中的应用汇总