Correlations of game centrality (GC) with degree, betweenness centrality and phenotypic potential of proteins in a high fidelity yeast interactome.

aSimulations of the prisoner’s dilemma game were performed as described in Methods using the parameter set of (R = 3, T = 6, S = 0, P = 1). Correlation values between degree, betweenness centrality, GC in prisoner’s dilemma game, as well as phenotypic potential [44] were calculated for the 2,444 proteins of the high fidelity yeast interactome of Ekman et al.[36]. bData represent Goodman-Kruskal’s gamma values ± standard errors. Significance levels in parentheses were also calculated using Goodman-Kruskal’s gamma test (the null hypothesis being that the correlation is different from zero). cUsing the R-package correlation test (http://personality-project.org/r/html/r.test.html, [62]) the correlation between phenotypic potential and game centrality was significantly larger than the correlation between phenotypic potential and degree, or the correlation between phenotypic potential and betweenness centrality.