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Total Synthesis of (+)-Pyrenolide D

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Figshare2018-09-25 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Total_Synthesis_of_-Pyrenolide_D/7130576
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An efficient approach to stereoselective construction of a spiro-γ-lactone core structure via BF3-promoted formal [3 + 2] annulation of aldehydo-aldose derivatives with γ-methylene-γ-butyrolactone has been developed. The spiro-γ-lactone derivative was then used in an efficient total synthesis of (+)-pyrenolide D. The developed chemistry paves the way for total synthesis of structurally diverse natural products containing spiro-lactone cores.
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2018-09-25
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