rat LDHA in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)-3-oxo-propyl)carbamoylamino)ethyl)phenyl)methyl) propanedioic acid

rat LDHA in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)-3-oxo-propyl)carbamoylamino)ethyl)phenyl)methyl) propanedioic acid Descriptor: (4-{2-[({3-[(2-METHYL-1,3-BENZOTHIAZOL-6-YL)AMINO]-3-OXOPROPYL}CARBAMOYL)AMINO]ETHYL}BENZYL)PROPANEDIOIC ACID, GLYCEROL, L-LACTATE DEHYDROGENASE A CHAIN Authors: Tucker, J.A, Brassington, C, Hassall, G, Watson, M, Ward, R, Tart, J, Davies, G, Caputo, A, Pearson, S. Deposit date: 2012-02-16 Release date: 2012-03-21 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation J.Med.Chem., 55, 2012

本数据集包含与配体2-((4-(2-((3-((2-甲基-1,3-苯并噻唑-6-基)氨基)-3-氧代丙基)氨基甲酰氨基)乙基)苯基)甲基)丙二酸结合的大鼠乳酸脱氢酶A（rat LDHA）复合物结构。描述项：(4-{2-[({3-[(2-甲基-1,3-苯并噻唑-6-基)氨基]-3-氧代丙基}氨基甲酰)氨基]乙基}苄基)丙二酸、甘油、L-乳酸脱氢酶A链。作者：Tucker, J.A.、Brassington, C.、Hassall, G.、Watson, M.、Ward, R.、Tart, J.、Davies, G.、Caputo, A.、Pearson, S.。沉积日期：2012-02-16。发布日期：2012-03-21。最后修改日期：2024-05-01。实验方法：X射线衍射（分辨率2.1埃）。引用文献：《基于片段导向先导物发现的新型乳酸脱氢酶A抑制剂的设计与合成》，发表于《Journal of Medicinal Chemistry》（J.Med.Chem.），2012年，第55卷。