Effect of gemcitabine in NOD-SCID mice with transplanted 634NOD cells.

Rat pancreas cancer cells (634NOD cells) were implanted subcutaneously into the flank of NOD-SCID mice. After 1 week the mice were administered gemcitabine (0 or 200 mg/kg, i.p.) four times within nine days by intraperitoneal injection. (A) Periodic observation of tumors in NOD-SCID mice treated with gemcitabine (0 mg/kg, open circles; 200 mg/kg, closed circles). (B) The tumor weight and (C) serum level of N-ERC/mesothelin was significantly decreased by treatment with gemcitabine (200 mg/kg, closed circles) compared to control (open circles) (P<0.05, P<0.01 respectively). (D) Correlation of tumor weight and serum levels of N-ERC/mesothelin. The serum level of N-ERC/mesothelin correlated with tumor weight and gemcitabine treatment (R = 0.966). Open circles, 0 mg/kg; closed circles, 200 mg/kg.