MLL_r_Model_Capture_WES

ranslocations involving the Mll1 (Kmt2a) gene generate powerful oncogenic fusion proteins, predominantly affecting infant and paediatric AML and ALL patients. The early stages of leukaemogenic transformation are typically inaccessible from human patients and conventional mouse models. We took advantage of conditionally immortalised multipotent haematopoietic progenitor cells to develop a new MLL-r model capturing the early cellular and molecular consequences of MLL-ENL expression based on a clear clonal relationship between the parental and leukaemic cells. In this project, we want to investigate the possibility of the acquisition of additional mutations that could be involved in the leukaemic potential of our model in vivo.