DNA binding regions of BMAL1 Core Circadian transcription factor in human T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia/lymphoma(T-ALL) is a malignancycurable in ~80% of pediatric and ~40% of adult patients. It is aheterogeneous disease characterized by the presence of leukemia stem cells(LSCs) which have been postulated to be responsible for relapses. Circadianclock circuitry modulates LSC activity in T-ALL. To identify the DNA bindingregions of BMAL1 core circadian transcription factor in T-ALL, we generatedChIP-seq data with BMAL1 in RPMI-8402 cell line. ChIP-seq was alsoperformed with the anti-H3K27me3 and anti-H3K27Ac antibodies to highlightactive and repressive genomic regions in RPMI-8402 cell line