Cognitive function in DMD carriers: personal case series and literature review

Introduction: This database includes the raw data linked with the paper “Cognitive function in DMD carriers: personal case series and literature review” published on “Acta Myologica”. Aim: This study aimed to investigate the cognitive involvement in a cohort of DMD carriers.

Methods: Our case series consisted of 22 carrier patients from two different centers (IRCCS Mondino, Pa- via and Policlinico Gemelli, Rome), for whom we retrospectively collected cognitive, clinical and genetic data.

Results: We found that the average IQ of DMD carriers was lower (74; very low) than the average score on normal curve (100 as average standard score). Furthermore, about 50% of them fell in the “extremely low IQ” range, compared with 2-3% of general population. A higher incidence of intellectual disability was confirmed  in symptomatic DMD carriers (mean IQ 66; extremely low) from the IRCCS Mondino, but not for the asymptomatic ones (mean IQ 99; average), when compared to the general population.