Model selection and proportion of time spent in the immobile state.

Diffusion coefficient units are nm2 s−1 with standard error based on the number of trajectories.1 Model selection between approximate one-state and two-state diffusion models with measurement noise, see Methods, with trajectories with no strong model preference (−3 eB1D, 2D 2 Fast switching trajectories (p^01>0.1 or p^10>0.1) also removed.3 Defined as logeD eD1 D, D1 nm2 s−1 from one-state and two-state diffusion models with measurement noise.4 Over all trajectories with either one-state or two-state model preference, with fast switching trajectories removed (i.e. Table notes 1 and 2 apply). For one-state preference, the proportion in the immobile state is 0 if logeD > 8, 1 if logeD > 8. For two-state preference, the proportion is 0 if logeD1 > 8, and if logeD1 z = 1 state (diffusion with D = D1), i.e. 1/N∑i=1Nπ(zi|X).5 Over all posterior samples, for trajectories with two-state model preference, with fast switching trajectories removed.6 Over all posterior samples, for trajectories with one-state model preference, restricted to logeD > 8.7 Over all posterior samples, for trajectories with one-state model preference, restricted to logeD Model selection and proportion of time spent in the immobile state.