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Effect of hepatocytic RKIP depletion on HFD-induced MASLD

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NIAID Data Ecosystem2026-05-10 收录
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High-fat diet (HFD) is a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), yet the molecular pathways that connect dietary fats to liver dysfunction remain unclear. Hepatocyte-specific RKIP depletion in male mice exacerbates ER stress, resulting in lipid droplets accumulation and MASLD progression. Overall design: RNA-seq profiling of liver tissues from HFD-fed RKIPf/f and Albcre-RKIPf/f mice.

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2026-02-25
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