A Tandem Semipinacol Rearrangement/Aldehyde Arylation or Alkylation of Trisubstituted 2,3-Epoxy Alcohols with Grignard Reagents for Functionalized 1,3-Diols
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下载链接：
https://figshare.com/articles/dataset/A_Tandem_Semipinacol_Rearrangement_Aldehyde_Arylation_or_Alkylation_of_Trisubstituted_2_3-Epoxy_Alcohols_with_Grignard_Reagents_for_Functionalized_1_3-Diols/20036839
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资源简介：
A tandem semipinacol rearrangement/aldehyde
arylation or alkylation
reaction leading to formation of functionalized 1,3-diols bearing
three consecutive tertiary stereocenters is identified from the reaction
of various new trisubstituted 2,3-epoxy alcohols with numerous Grignard
reagents. This reaction is useful for stereoselective construction
of three consecutive tertiary stereocenters. The observed 1,3-diols
exist in the anti configuration, which is confirmed
by two-dimensional nuclear Overhauser effect spectroscopy, the crystal
structure of acetonide of 1,3-diol analogue 3ai, and
further density functional theory studies.
创建时间：
2022-06-09
