Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells

SASP from endothelial cells experiencing therapy-induced senescence promotes the aggressive behavior of cancer cells, and that CXCL11 could potentially be targeted to prevent the adverse effects of therapy-induced senescent endothelial cells on the tumor microenvironment.

由经历治疗诱导性衰老的内皮细胞产生的SASP可促进癌细胞的侵袭行为，且CXCL11有望被靶向以防止治疗诱导性衰老内皮细胞对肿瘤微环境的不良影响。