Data from: Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance

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Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been implicated in hepatic steatosis and insulin resistance. The present study investigated their roles in the development of hepatic steatosis and insulin resistance during de novo lipogenesis (DNL) compared to extrahepatic lipid oversupply. Male C57BL/6J mice were fed either a high fructose (HFru) or high fat (HFat) diet to induce DNL or lipid oversupply in/to the liver. Both HFru and HFat feeding increased hepatic triglyceride within 3 days (by 3.5 and 2.4 fold) and the steatosis remained persistent from 1 week onwards (p

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内质网（endoplasmic reticulum, ER）应激与线粒体功能障碍已被证实与肝脂肪变性及胰岛素抵抗存在关联。本研究对比探讨了二者在从头脂肪生成（de novo lipogenesis, DNL）过程中，相较于肝外脂质过量负荷时，对肝脂肪变性及胰岛素抵抗发生发展的作用。本研究选用雄性C57BL/6J小鼠，分别给予高果糖（high fructose, HFru）饮食与高脂肪（high fat, HFat）饮食，以诱导肝脏内的从头脂肪生成或脂质过量负荷。高果糖与高脂肪饮食干预均可在3天内升高肝脏甘油三酯水平（分别达到对照组的3.5倍与2.4倍），且肝脂肪变性状态自干预1周起持续存在（p