Data from: Semisynthesis and insecticidal activity of some novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety

Two series of novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety were prepared as insecticidal agents against the oriental armyworm, Mythimna separata Walker. The structural assignment was based on the spectroscopic and X-ray analysis data. Among all the target compounds, compounds 4b, 4k, 5b, 5j and 5k exhibited more potent insecticidal activity with final mortality rates (FMRs) of > 65%, especially 4k with the FMR of 75.9%, when compared with toosendanin. Some interesting results of structure–activity relationships were also discussed.本研究合成了两类含1,3,4-噁二唑（1,3,4-oxadiazole）基团的新型白蜡树酮（fraxinellone）基硫醚类化合物，将其作为杀虫剂用于防治东方粘虫（Mythimna separata Walker）。所有目标化合物的结构均基于光谱学数据与X射线衍射分析得以确证。在全部受试目标化合物中，4b、4k、5b、5j与5k展现出优于川楝素（toosendanin）的杀虫活性，其最终死亡率（final mortality rates, FMRs）均高于65%；其中化合物4k的最终死亡率达75.9%，活性最为突出。本研究同时探讨了该类化合物构效关系的相关有趣发现。