Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11J

Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11J Descriptor: 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14 Authors: Sack, J.S. Deposit date: 2007-10-02 Release date: 2008-01-15 Last modified: 2025-11-12 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors J.Med.Chem., 51, 2008

苯丙氨酸衍生吡咯并三嗪类p38α丝裂原活化蛋白激酶（Mitogen-activated protein kinase, MAPK）抑制剂化合物11J 描述项：4-[[5-(甲氧甲酰氨基)-2-甲基苯基]氨基]-5-甲基-N-[(1S)-1-苯乙基]吡咯并[2,1-f][1,2,4]三嗪-6-甲酰胺，为丝裂原活化蛋白激酶14（Mitogen-activated protein kinase 14, MAPK14）抑制剂。作者：J.S.萨克（Sack, J.S.）。入库日期：2007-10-02；发布日期：2008-01-15；最后修改日期：2025-11-12。测定方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.72埃（Å）。引用文献：《口服活性4-(苯氨基)吡咯并[2,1-f][1,2,4]三嗪类p38α丝裂原活化蛋白激酶抑制剂的设计、合成与抗炎活性》，载于《药物化学杂志》（J.Med.Chem.），2008年，第51卷。