A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (PPARG) recruits pparg-coactivator-1 alpha (PGC1A) but potentiates insulin signaling in vitro

A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (PPARG) recruits pparg-coactivator-1 alpha (PGC1A) but potentiates insulin signaling in vitro Descriptor: 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-4-{[4-(2-METHOXYPHENYL)PIPERIDIN-1-YL]METHYL}ISOQUINOLINE, GLYCEROL, Nuclear receptor coactivator 1, ... Authors: Benz, J, Burgermeister, E, Flament, A, Schnoebelen, A, Stihle, M, Gsell, B, Rufer, A, Ruf, A, Kuhn, B, Maerki, H.P, Mizrahi, J, Sebokova, E, Niesor, E, Meyer, M. Deposit date: 2006-01-31 Release date: 2006-05-16 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.99 Å) Cite: A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro Mol.Endocrinol., 20, 2006

一种新型抗脂肪生成的过氧化物酶体增殖物激活受体γ（peroxisome proliferator-activated receptor-gamma, PPARG）部分激动剂，可募集过氧化物酶体增殖物激活受体γ辅激活因子1α（PPARγ-coactivator-1 alpha, PGC1A）并在体外增强胰岛素信号转导
描述符：1-(3,4-二甲氧基苄基)-6,7-二甲氧基-4-{[4-(2-甲氧基苯基)哌啶-1-基]甲基}异喹啉、甘油、核受体辅激活因子1（Nuclear receptor coactivator 1）……
作者：Benz J、Burgermeister E、Flament A、Schnoebelen A、Stihle M、Gsell B、Rufer A、Ruf A、Kuhn B、Maerki H.P、Mizrahi J、Sebokova E、Niesor E、Meyer M
存档日期：2006-01-31
发布日期：2006-05-16
最后修改日期：2024-04-03
实验方法：X射线衍射（1.99 Å）
引用文献：一种新型过氧化物酶体增殖物激活受体γ部分激动剂可募集PPARγ辅激活因子1α、抑制甘油三酯积累并在体外增强胰岛素信号转导，《分子内分泌学》（Mol.Endocrinol.），20卷，2006年