A Review on Probable Lysosomotropic Properties of Sodium Bicarbonate to Restrain Viral Entry of Coronavirus 2 (SARS-CoV-2)

SARS-CoV-2 causing COVID-19 has appeared as an ongoing global public crisis, growing with geometric progression and has caused huge devastation till date majorly because of lack of targeted therapeutic agents like vaccines. The entry of Coronavirus-2 into host cells being acidic pH dependent. Thus, in the current clinical emergency there is a pressing need to look forward for adjunct therapies which could counter the acidic pH, so as to restrain the viral entry and its subsequent reproduction in the host cells. Therefore, the current review attempted to explore the possibility to use sodium bicarbonate as an alternative lysosomotropic agent based on the reported literature owing to its anti-flu properties and widespread use during Spanish pandemic of 1918. The suggestions put forward in the current review article based on the careful use of sodium bicarbonate could probably help to restrain SARS-CoV-2 infection.

SARS-CoV-2导致的COVID-19疫情已成为一场持续的全球公共卫生危机，其蔓延呈几何级数增长，造成了巨大的灾难，这主要归因于缺乏针对性的治疗药物，如疫苗。冠状病毒-2进入宿主细胞的过程依赖于酸性pH值。因此，在当前的医疗紧急情况下，迫切需要寻求辅助治疗措施，以对抗酸性pH值，从而抑制病毒进入宿主细胞及其在宿主细胞中的后续复制。因此，本综述旨在基于已报道的文献，探讨使用碳酸氢钠作为替代性溶酶体趋化剂的可行性，鉴于其抗流感特性和在1918年西班牙流感大流行期间的广泛应用。本综述文章中提出的建议，基于对碳酸氢钠的谨慎使用，或许有助于抑制SARS-CoV-2的感染。