miRNA expression data from a cohort of Chilean Ulcerative Colitis human intestinal samples

MicroRNAs have been associated with the pathogenesis of intestinal diseases such as colon cancer and are deregulated in the inflammatory environment of intestinal mucosa in UC patients. The effects of microRNAs on immunological factors have been described before, however, there is no evidence that they have an effect on alarmins that impact on the pathophysiology of UC. Our goal is to identify deregulated miRNAs to be paired with potential target mRNAs. We used microarrays to compare inflamed and non inflamed mucosa from chilean ulcerative colitis patients Inflamed and non inflamed human Intestinal biopsies were obtained in colonoscopy from Ulcerative Colitis patients and total RNA were extracted and hybridized using Affymetrix Eukaryotic Target Hybridization Controls protocol. MicroRNAs were extracted and then hybridized with Affymetrix MicroRNA microarray was accomplished using the Affymetrix GeneChipTM Version 4 microRNA arrays following the Affymetrix hybridization protocols (ThermoFisher Scientific Santa Clara, CA).