Reproductive factors and risk of B-cell non-Hodgkin's lymphomas among women in Los Angeles

Unrestricted Study Aim: Reproductive patterns have been inconsistently linked to NHL risk. The aim of this study is to identify if these factors affect B-cell NHL risk among women. Methods: We conducted a population-based case-control study in Los Angeles County. A total of 555 histologically confirmed B-cell NHL patients and 555 individually matched control subjects were included. Conditional logistic regression was used to evaluate these associations. Results: Reproductive history factors such as gravidity, parity, and outcome of first pregnancy were not associated with B-cell NHL risk overall or any NHL subtype. A modest association was observed for use of lactation suppressants (OR=0.78, 95% CI=0.56-1.08). The use of diethylstilbestrol (DES) during pregnancy increased the risk of B-cell NHL (OR=2.10, 95% CI=0.71-6.23). Conclusion: Reproductive factors were not associated with the risk of B-cell NHL overall or any subtype. Future studies with greater numbers of NHL subtypes are needed to confirm our study results.研究目标：生殖模式与非霍奇金淋巴瘤（Non-Hodgkin Lymphoma, NHL）风险的关联在既往研究中结论不一。本研究旨在明确此类生殖相关因素是否会影响女性罹患B细胞非霍奇金淋巴瘤（B-cell NHL）的风险。研究方法：本研究在洛杉矶县开展基于人群的病例对照研究，共纳入555例经组织学确诊的B细胞非霍奇金淋巴瘤患者，以及555例个体匹配对照受试者。采用条件logistic回归分析评估上述关联。研究结果：生殖史相关因素，包括妊娠次数、产次及首次妊娠结局，与总体B细胞非霍奇金淋巴瘤风险或任一NHL亚型风险均无显著关联。使用泌乳抑制剂存在微弱关联（比值比（Odds Ratio, OR）=0.78，95%置信区间（95% confidence interval, 95% CI）=0.56~1.08）。妊娠期使用己烯雌酚（diethylstilbestrol, DES）可升高B细胞非霍奇金淋巴瘤的发病风险（OR=2.10，95% CI=0.71~6.23）。研究结论：总体而言，生殖相关因素与B细胞非霍奇金淋巴瘤风险或任一NHL亚型风险均无显著关联。未来需开展纳入更多NHL亚型的研究，以验证本研究结果。