Supplementary Material for: Bullous Lichen Planus Treated with Adalimumab: A Case Report

Introduction: Bullous lichen planus is a rare variant of lichen planus that is characterized by vesiculo-bullous lesions developing in the setting of pre-existing LP lesions with a burning and painful feeling. Bullous lichen planus treatment is difficult since so few examples of the condition have been documented in the literature.
Case Presentation: A 46-year-old female, presented to our outpatient clinic with pruritic violaceous bullae involving lower extremities and oral mucosa for 8 years. After extensive investigations a diagnosis of bullous lichen planus was made and successfully treated with adalimumab after failure of other treatment options.
Conclusion: Adalimumab may represent a promising, efficacious, and safe monotherapy option for the management of bullous lichen planus. The therapeutic value of this novel off-label use should be assessed in controlled clinical trials.