Table_1_Plasma pentosidine as a useful biomarker of sarcopenia, low gait speed, and mortality in patients with cirrhosis.docx

PurposeThe accumulation of advanced glycation end products (AGEs) is associated with various diseases and age-related impairments, including loss of muscle mass and function. We investigated the association between plasma pentosidine, which is one of the AGEs, and sarcopenia, low gait speed, and mortality in patients with cirrhosis.MethodsThis retrospective study divided 128 patients with cirrhosis into three groups by 25th and 75th quartiles of baseline plasma pentosidine levels: low (L)-, intermediate (I)-, and high (H)-pentosidine (Pen) groups. Sarcopenia was diagnosed following the Japan Society of Hepatology criteria. Low gait speed was defined as

目的：高级糖化终产物（AGEs）的累积与多种疾病及与年龄相关的功能障碍相关，包括肌肉质量和功能的丧失。本研究旨在探讨血浆戊糖胺（一种AGEs）与肝硬化患者肌少症、行走速度降低及死亡率之间的关联。方法：本研究为回顾性研究，将128例肝硬化患者根据基线血浆戊糖胺水平的中位数分为三个组别：低戊糖胺（L）组、中间戊糖胺（I）组和高戊糖胺（H）组。肌少症的诊断依据日本肝脏学会的标准。行走速度降低被定义为...