Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
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Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor Descriptor: 2-[(4R)-4-(4-cyanophenyl)-5-ethanoyl-6-methyl-2-oxidanylidene-1-[3-(trifluoromethyl)phenyl]-4H-pyrimidin-3-yl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, NEUTROPHIL ELASTASE, ... Authors: vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A. Deposit date: 2015-04-17 Release date: 2015-08-19 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem, 10, 2015
人中性粒细胞弹性蛋白酶（human neutrophil elastase）与二氢嘧啶酮类抑制剂共晶的晶体结构
描述物：2-[(4R)-4-(4-氰基苯基)-5-乙酰基-6-甲基-2-氧亚基-1-[3-(三氟甲基)苯基]-4H-嘧啶-3-基]乙酸、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、中性粒细胞弹性蛋白酶……
作者：vonNussbaum, F、Li, V.M.-J、Allerheiligen, S、Anlauf, S、Baerfacker, L、Bechem, M、Delbeck, M、Fitzgerald, M.F、Gerisch, M、Gielen-Haertwig, H、Haning, H、Karthaus, D、Lang, D、Lustig, K、Meibom, D、Mittendorf, J、Rosentreter, U、Schaefer, M、Schaefer, S、Schamberger, J、Telan, L.A、Tersteegen, A.
保藏日期：2015-04-17
发布日期：2015-08-19
最后修改日期：2024-10-16
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.81埃（Å）
引用文献：《冻结生物活性构象以提升效力：BAY 85-8501的发现——一种用于肺部疾病的高选择性强效人中性粒细胞弹性蛋白酶抑制剂》，刊载于ChemMedChem，第10卷，2015年
创建时间：
2015-04-17
