Hit and lead compounds identified from chemical libraries using the ex vivo splenic explant system.

1NINDS Col II (NINDS Collection II, MicroSource Discovery Systems).2NINDS NP (NINDS Natural Products Collection, MicroSource Discovery Systems).3Diversity set and Natural products set of the National Cancer Institute (NCI).4Compounds identified by Z score, excluding the toxic compounds (CC50 5Total number (No.) and % of compounds excluding amphotericin B, which is considered as the reference compound.6All percentages shown in the table refer to the total number of compounds of the initial screening. See Table S1 for compound details.7Leads identified using the in vitro therapeutic index (IVTI) calculated of the cell toxicity (CC50) and anti-Leishmania activity (EC50) ratio.