Genes disrupted or deleted entirely in breast cancer cases and involved in TP53 and β-estradiol centered network.

Disruption = the gene is disrupted by the CNV breakpoints; deletion = the entire gene is deleted. del = partial gene deletion; dup = partial gene duplication.aBased on human genome assembly 19 (February 2009).bAlthough detailed effects of partial gene duplication to gene transcription are not clear, duplication have potential to disrupt transcription by several mechanisms, such as transcriptional read-through. This can occur by tandem duplication, where gene silencing can be induced by a partially duplicated (3′ deleted) version of the gene itself [54].